No. 20 Oklahoma State and No. 23 Kansas State both suffered disappointing losses in the Big 12 last week, but with the expansion to 12 teams, they still have a shot at winning their conferences and making the College Football Playoff. The two teams face off on Saturday at noon ET with a chance to bounce back with a key conference win. The Wildcats host the Cowboys, who are 6-point favorites in the Week 5 college football odds, according to SportsLine consensus.
Meanwhile, in another Top 25 matchup, No. 9-ranked Penn State in the Big Ten holds a 17.5-point home favorite over No. 19 Illinois. So, should you bet on Penn State vs. Illinois or Oklahoma State vs. Kansas State? And what Week 5 college football lines should you bet on this weekend? Before locking in your Week 5 college football predictions for these and any other game, be sure to check the latest college football predictions from SportsLine's Proven Model.
The model simulates FBS college football games 10,000 times. Since inception, the model has generated well over $2,000 in profits for players who spend $100 on the top rated college football picks against the spread. The model also just finished a season with a profitable 13-9 record on its top rated spread picks. Anyone who has followed this model has seen significant profits.
We're currently looking at the latest college football odds and college football betting lines for the spread, moneyline and over/under for Week 5. Click here to see all our picks.
Top college football predictions for Week 5
One college football pick the model rates highly for Week 5: No. 16 Notre Dame (-6.5) to beat No. 15 Louisville by double digits in a matchup at 3:30 PM ET on Saturday. Louisville ruined Notre Dame's season last year, so the Fighting Irish are in for some big revenge this week. Quarterback Riley Leonard has already scored six rushing touchdowns for Notre Dame in blowout wins over Purdue and Miami (Ohio).
Louisville is on the road for the first time this season and ranks 90th in passing yards allowed, so Leonard has a chance to use his arm and legs to spread the field on Saturday. The Cardinals have already struggled to slow down the mobile quarterback this season, and this is a bad matchup for them. Notre Dame has covered the spread in five of their last seven games, and our model has the Fighting Irish covering in 60% of the simulations. See the rest of our college football picks for Week 5 here.
Another prediction: No. 21 Oklahoma (-2.5) will comfortably beat Auburn on Saturday with a 3:30 p.m. ET kickoff. The Sooners made their SEC debut against Tennessee last week, losing 25-15 at home. But the Sooners held the Volunteers to nearly 40 points less than their season scoring average this week, and the change in quarterback from Jackson Arnold to Michael Hawkins Jr. seemed to revitalize the offense down the stretch.
Hawkins led the Sooners on two fourth-quarter scoring drives, completing 11 of 18 for 132 yards and a touchdown, and ran for another 22 yards. Meanwhile, Auburn was lackluster in a 24-14 loss to Arkansas last week and scored just 14 points against California, its only game against a strong conference opponent. That's a big reason why the model projects Oklahoma to cover the spread in more than 60 percent of simulations on its way to its first SEC win in program history. You can see our predictions for all other Week 5 gameplay here.
How to predict college football for Week 5
The model also predicts who will win and cover every FBS matchup in Week 5, and predicts a whopping 10 underdog teams to win, including an upset in one of the biggest games of the week. You can get every prediction for every game only at SportsLine.
So which teams should win to make college football picks with confidence, and which 10 underdogs will win in Week 5? Check out the latest college football odds below, then visit SportsLine to find out which teams will win and cover the spread, all from a proven computer model that's generated over $2,000 in profits since inception.
Week 5 college football odds
Click here for more Week 5 college football picks, odds and predictions
Thursday, September 26
Templar Army (+12.5, 46)
Friday, September 27
Virginia Tech vs. Miami (-19.5, 54.5)
Washington vs. Rutgers (-2.5, 44.5)
Saturday, September 28
BYU vs. Baylor (-3.5, 45.5)
Oklahoma State vs. Kansas State (-4.5, 55)
Kentucky vs. Ole Miss (-17.5, 53)
Minnesota vs. Michigan (-9.5, 35.5)
Louisville at Notre Dame (-6.5, 45)
Colorado vs. UCF (-14, 65)
Oklahoma vs. Auburn (+2.5, 45.5)
Wisconsin vs. USC (-15.5, 51.5)
Mississippi State vs. Texas (-38.5, 62.5)
Ohio State vs. Michigan (+23.5, 48.5)
Georgia vs. Alabama (+2, 48.5)
Illinois vs. Penn State (-17.5, 47.5)
Oregon vs. UCLA (+25.5, 55.5)
